The 2021 IEEE International Conference on Systems, Man, and Cybernetics (SMC 2021), is the flagship conference of the IEEE Systems, Man, and Cybernetics Society. It provides an international forum for researchers, educators and practitioners to learn, share knowledge, report most recent innovations and developments, and to exchange ideas and advances in all aspects of systems science and engineering, human-machine systems, and cybernetics.  Conference Page: http://ieeesmc2021.org Submission Page: https://conf.papercept.net/conferences/scripts/start.pl Deadlines Submission of Proposals for Special Sessions: March 1, 2021 Submission of Regular Papers, Industrial Papers, and Tutorial and Workshop proposals: April 5, 2021 Final camera-ready Regular, Special Session, Industrial and Workshop Papers: July 12, 2021 Deadline for early registration: August 2, 2021 IEEE SMC 2021 Saeid Nahavandi (General Chair) Peng Shi & Edward Tunstel (Honorary General Co-Chairs) Anthony Maciejewski (Program Chair)