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In Silico Modelling in Support of Neurostimulation: Device Development, Treatment Optimization and Mechanistic Investigations

November 3, 2021 @ 2:00 pm - 3:00 pm

In the last decade, there has been an increased interest in proposing, investigating, manufacturing – and therefore in regulating – novel medical approaches and technologies complementary or even competitive to the traditional pharmacological and surgical ones that are aimed at recovering lost body functionalities (e.g., limb movement) or at relieving medical conditions derived from compromised organ functions. The goal of bioelectronic medicine is the use of smart devices to ensure efficient, safe and personalized medical treatment through the precise and therapeutic delivery of physical agents (electromagnetic fields, heat, acoustic waves, etc.) to the nervous system. In silico modelling is widely used to facilitate the development and the optimization of these technologies (e.g., electroceuticals) and allows mechanistic investigations, the identification and and estimation of treatment-related quantities of interest (QoIs) (e.g. specific dose and dose metrics), the investigation of safety and performance related aspects (e.g. dose uncertainty) as well as personalized treatment. In this talk the challenges faced by bioelectronic medicine will be discussed, and the in silico methods developed to facilitate the engineering of multiple neurostimulation-related technologies (including electroceuticals, spinal cord and deep brain stimulators, as well as non-invasive brain stimulation devices) are discussed. Speaker(s): Dr. Antonino Cassara, Montreal, Quebec, Canada, Virtual: https://events.vtools.ieee.org/m/287023